Final stages in escort aptamer planning involve artificial adjustment of truncated aptamer
Final stages in escort aptamer planning involve artificial adjustment of truncated aptamer Further nuclease stabilization is achieved by substitution of 2?-OCHstep 3 for 2?-OH at purine positions. As the 2?-OCH3 moiety is not compatible with current SELEX process enzymes, this alteration must occur during chemical synthesis following evolution of a specific aptamer sequence. Generally, most…